INVESTIGATING THE MECHANISM OF ACTION OF DIKETOPIPERAZINES INHIBITORS OF THE BURKHOLDERIA CENOCEPACIA QUORUM SENSING SYNTHASE CEPI: A SITE-DIRECTED MUTAGENESIS STUDY

Quorum sensing (QS) is a bacterial intercellular communication process which controls the production of major virulence factors, such as proteases, siderophores, and toxins, as well as biofilm formation.Since the inhibition of this pathway reduces bacterial virulence, QS is considered a valuable candidate drug target, particularly for the treatment

At present, cancer is the first cause of death for humans, but early detection and treatment can help improve prognoses and reduce mortality.However, Disney further development of copyright-assistant drug delivery systems (DDSs) is retarded by the aspects such as the low drug-carrying capacity, copyright-induced toxicity and immunogenicity, complex

Abstract Background COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality.At the time this clinical trial was planned, there were no available vaccine or therapeutic agents with proven efficacy, but the severity of the condition prompted the use of several pharmacological and non

Our ability to sustain attention for prolonged periods of time is limited.Studies on the relationship between lapses of attention and psychophysiological markers of attentional state, such as pupil diameter, Hayward Main Drain Parts have yielded contradicting results.Here, we investigated the relationship between tonic fluctuations in pupil diamete